| Pos | Player | Matchup | Pts | Proj | Status |
|---|---|---|---|---|---|
| Starters9 | |||||
| QB |  Brock PurdySF Bye 8 |
@SEASun 3:05pm CT | 0.00 | 21.48 | Starter |
| RB |  Tony PollardTEN Bye 9 |
@DENSun 3:05pm CT | 0.00 | 10.95 | Starter |
| RB |  Kyren WilliamsLAR Bye 11 |
HOUSun 3:25pm CT | 0.00 | 12.92 | Starter |
| WR |  Terry McLaurinWAS Bye 7 |
NYGSun 12:00pm CT | 0.00 | 12.91 | Starter |
| WR |  Michael Pittman Jr.PIT Bye 9 |
@NYJSun 12:00pm CT | 0.00 | 11.30 | Starter |
| WR |  Michael WilsonARI Bye 14 |
@NOSun 12:00pm CT | 0.00 | 10.42 | Starter |
| TE |  Tyler WarrenIND Bye 13 |
MIASun 12:00pm CT | 0.00 | 11.67 | Starter |
| K |  Brandon AubreyDAL Bye 14 |
@PHIThu 7:20pm CT | 0.00 | 10.34 | Starter |
| D/ST |  Denver BroncosDEN Bye 10 |
TENSun 3:05pm CT | 0.00 | 3.76 | Starter |
| Bench15 | |||||
| QB |  Fernando MendozaLV Bye 13 |
@NESun 12:00pm CT | 0.00 | 13.80 | Bench |
| RB |  Tank BigsbyPHI Bye 10 |
DALThu 7:20pm CT | 0.00 | 3.24 | Bench |
| RB |  Jaydon BlueDAL Bye 14 |
@PHIThu 7:20pm CT | 0.00 | 3.20 | Bench |
| RB |  Demond ClaiborneMIN Bye 6 |
@CHIMon 7:15pm CT | 0.00 | 1.66 | Bench |
| RB |  Jordan MasonMIN Bye 6 |
@CHIMon 7:15pm CT | 0.00 | 7.98 | Bench |
| RB |  Keaton MitchellLAC Bye 7 |
KCFri 7:00pm CT | 0.00 | 4.56 | Bench |
| RB |  Nicholas SingletonTEN Bye 9 |
@DENSun 3:05pm CT | 0.00 | 2.02 | Bench |
| RB |  Mike Washington Jr.LV Bye 13 |
@NESun 12:00pm CT | 0.00 | 4.58 | Bench |
| WR |  Jalen CokerCAR Bye 5 |
@JAXSun 12:00pm CT | 0.00 | 8.76 | Bench |
| WR |  Omar Cooper Jr.NYJ Bye 13 |
PITSun 12:00pm CT | 0.00 | 8.31 | Bench |
| WR |  Matthew GoldenGB Bye 11 |
DETSun 3:25pm CT | 0.00 | 8.41 | Bench |
| WR |  Jalen McMillanTB Bye 10 |
@ATLSun 12:00pm CT | 0.00 | 6.75 | Bench |
| TE |  Mark AndrewsBAL Bye 13 |
@BUFSun 7:20pm CT | 0.00 | 8.53 | Bench |
| TE |  Terrance FergusonLAR Bye 11 |
HOUSun 3:25pm CT | 0.00 | 4.91 | Bench |
| D/ST |  New England PatriotsNE Bye 11 |
LVSun 12:00pm CT | 0.00 | 4.58 | Bench |
